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Trains from Lewes are run by the Southern Railway Direct trains will take you to Eastbourne, Hastings, Ashford, Brighton, Haywards Heath, Croydon and London.

Change trains and you could go anywhere. 3 changes of train will get you to Moscow and 6 changes will get you to Istanbul.

Fares vary widely- a ticket to London could cost you £2 or £20. This site has information about the best deals.